Development and validation of novel stability indicating RP-HPLC method for the determination of assay of voriconazole in pharmaceutical products

For the determination of assay voriconazole in bulk and pharmaceutical dosage forms, a novel stability indicating RP-HPLC method was designed validated, exhibiting very low run time. The stability-indicating nature approach is supported by fact that it unique, quick, precise, accurate, capable isolating peak from any contaminating or degrading components. Isocratic elution on 100 mm x 4.6 mm, 3μm agilent C18 column at 45°C UV detection wavelength 256 nm constitutes analytical procedure flow rate 1.0 mL/min. After injecting 20µL sample, occurred 3.5 minutes, entire time 15 minutes. Between 98% 102% reasonable range for percentage recovery. It determined method's RSD precision accuracy less than 2%. has been verified routine analysis materials its formulations according to standards established International Conference Harmonization (ICH).